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Northwestern University Feinberg School of Medicine
Center for Genetic Medicine
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Past Lectures

 Genomic Landscape of Breast Cancer in Diverse Populations
Olufunmilayo (Funmi) I. Olopade, MD, FACP, OONFebruary 5, 2019

Dissolving knowledge gaps that contribute to health care disparities requires adequate inclusions of diverse populations in genomic studies. Olufunmilayo (Funmi) I. Olopade, MD, FACP, OON, is Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics; Associate Dean for Global Health; and Director, Center for Clinical Cancer Genetics, The University of Chicago. Olopade discussed ongoing research in her group to gain a better understanding of the biological basis of cancer’s heterogeneity across genetic and geographic contexts.

 Flies and Alcohol: Interplay of Nature and Nurture
Ulrike Heberlein, PhD October 11, 2016

Ulrike Heberlein, PhD, is a senior fellow and laboratory head at the Janelia Research Campus of HHMI. Heberlein uses the fruit fly Drosophila as a model organism to study the neural and molecular mechanisms underlying drug abuse and addiction. She discussed the mechanisms by which social experiences and stress affect alcohol behaviors.

 Epigenetic Defense Mechanisms: Coping with Transposable Elements in the Drosophila Genome
Sarah C. R. Elgin, PhD October 14, 2014

Sarah C. R. Elgin, PhD, is Victor Hamburger Professor of Arts & Sciences, professor of biology and professor of genetics, Washington University in St. Louis and investigator at Howard Hughes Medical Institute. Elgin discussed eukaryotic genomes, which contain high levels of transposable elements (TEs), and their remnants, DNA that is commonly packaged for silencing in heterochromatin. Elgin models how such silencing occurs at the nucleosome level with the fruit fly Drosophila melanogaster, utilizing an alternative pattern of histone modification with association of heterochromatin-specific proteins, notably HP1.

 Genomic Profiling and Translational Research: Study Designs, Analyses and Applications
Nicholas Schork, PhD March 4, 2014

Nicholas J. Schork, PhD, is director of Biostatistics and Bioinformatics, Scripps Translational Science Institute; director of Research, Scripps Genomic Medicine; professor, Department of Molecular and Experimental Medicine, The Scripps Research Institute; and professor of Psychiatry and Biostatistics (adjunct), University of California San Diego. Schork described studies that use genomic profiling to further translational research, focusing on the formidable issues of patient genetic background heterogeneity, matching drugs to tumor genomic profiles in real-time clinical trial settings and the utility of personalized therapeutic interventions.

 Genome Sequencing: Discovery and Clinical Applications
Gail Jarvik, MD, PhDJune 4, 2013

Gail Jarvik, MD, PhD, is head of the Division of Medical Genetics, the Arno G. Motulsky Endowed Chair in Medicine and professor of Genome Sciences at the University of Washington Medical Center. Jarvik discussed emerging issues in clinical genomics, including the return of incidental genomic findings. She also gave an example of the use of genomics to solve the genetic basis of a clinic patient with a novel presentation.

 Globally Monitoring Translation One Codon at a Time with Ribosome Profiling
Jonathan Weissman, PhDMay 29, 2012

Jonathan S. Weissman, PhD, professor of Cellular & Molecular Pharmacology and Biochemistry & Biophysics, University of California, San Francisco, and investigator at Howard Hughes Medical Institute, discussed the suite of ribosome profiling techniques developed by his laboratory that dramatically expand the ability to follow translation in vivo.

 Telomeres, Telomerase and Association with Human Disease
Thomas Cech, PhDApril 5, 2011

Thomas R. Cech, PhD, is distinguished professor, University of Colorado-Boulder; director of Colorado Initiative in Molecular Biotechnology and investigator at Howard Hughes Medical Institute. Cech discussed his laboratory’s research on large noncoding RNAs, where catalysis is carried out by ribonucleoproteins. He described recent research on telomerase and its interaction with chromosome ends.

 Resetting Metabolism: Nuclear Receptors and AMPK
Ronald Evans, PhDJune 1, 2010

Ronald M. Evans, PhD, is professor & March of Dimes chair, Molecular and Developmental Biology, Salk Institute for Biological Studies, and investigator at Howard Hughes Medical Institute. Evans shared his current research on the genetic basis of obesity-related diseases, including diabetes, high blood pressure, heart disease and insulin resistance.

 Communicating with Hedgehogs: Signaling in Development and Disease
Matthew Scott, PhDMay 5, 2009

Matthew Scott, PhD, is professor of Developmental Biology, Genetics and Bioengineering, Stanford University School of Medicine, and investigator at Howard Hughes Medical Institute.

 Return to RNAi World: Rethinking Gene Expression, Evolution and Medicine
Craig Mello, PhDMay 13, 2008

Craig C. Mello, PhD, is the Blais University Chair in Molecular Medicine, University of Massachusetts Medical School, and investigator at Howard Hughes Medical Institute.

 Using Simple Cells to Unlock Complex Secrets of Biology
Susan Lindquist, PhDMarch 27, 2007

Susan Lindquist, PhD is a member of the Whitehead Institute for Biomedical Research and professor in the Department of Biology at MIT. Lindquist is a pioneer in the study of protein folding. She has shown that changes in protein folding can have profound and unexpected influences in fields as wide-ranging as human disease, evolution and nanotechnology.

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 Human Genome Sequence Variation and the Inherited Basis of Common Disease
David Altshuler, MD, PhDMay 30, 2006

David Altshuler, MD, PhD, is associate professor of Genetics and Medicine at Harvard Medical School and director of the Program in Medical and Population Genetics at the Broad Institute of Harvard and MIT.

 Genes for Heart, Kidney and Bone Disease: New Insights from Human Genetic Studies
Richard P. Lifton, MD, PhDApril 19, 2005

Richard P. Lifton, MD, Ph,D is chair of Genetics and Professor of Internal Medicine, Genetics, Molecular Biophysics and Biochemistry at Yale University School of Medicine and investigator at Howard Hughes Medical Institute.

 Of Genes and Genomes
David Botstein, PhDApril 20, 2004

David Botstein, PhD, is Anthony B. Evnin Professor of Genomics and director of Lewis-Sigler Institute for Integrative Genomics at Princeton University.

 Human Genomic Variation in Complex Disease
Aravinda Chakravarti, PhDApril 29, 2003

Aravinda Chakravarti, PhD, is a professor and the director of the McKusick-Nathans Institute of Genetic Medicine at The Johns Hopkins University School of Medicine. Chakravarti’s research is aimed at genomic-scale analysis of the human genome and understanding the molecular genetic basis of common genetic disorders using contemporary genomic tools.

 The Genome’s Language
Patrick Brown, MD, PhDDec. 4, 2001

Patrick O. Brown, MD, PhD, is a professor in the Department of Biochemistry at Stanford University School of Medicine and investigator at Howard Hughes Medical Institute. Brown led the development of DNA microarrays, or "gene chip" technology.
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