Flies and Alcohol: Interplay of Nature and NurtureUlrike Heberlein, PhD - Oct. 11, 2016
Ulrike Heberlein, PhD, is a senior fellow and laboratory head at the Janelia Research Campus of HHMI. Heberlein uses the fruit fly Drosophila as a model organism to study the neural and molecular mechanisms underlying drug abuse and addiction. She discussed the mechanisms by which social experiences and stress affect alcohol behaviors.
Epigenetic Defense Mechanisms: Coping with Transposable Elements in the Drosophila GenomeSarah C. R. Elgin, PhD - Oct.14, 2014
Sarah C. R. Elgin, PhD, is Victor Hamburger Professor of Arts & Sciences, professor of biology and professor of genetics, Washington University in St. Louis and investigator at Howard Hughes Medical Institute. Elgin discussed eukaryotic genomes, which contain high levels of transposable elements (TEs), and their remnants, DNA that is commonly packaged for silencing in heterochromatin. Elgin models how such silencing occurs at the nucleosome level with the fruit fly Drosophila melanogaster, utilizing an alternative pattern of histone modification with association of heterochromatin-specific proteins, notably HP1.
Genomic Profiling and Translational Research: Study Designs, Analyses and ApplicationsNicholas Schork, PhD - March 4, 2014
Nicholas J. Schork, PhD, is director of Biostatistics and Bioinformatics, Scripps Translational Science Institute; director of Research, Scripps Genomic Medicine; professor, Department of Molecular and Experimental Medicine, The Scripps Research Institute; and professor of Psychiatry and Biostatistics (adjunct), University of California San Diego. Schork described studies that use genomic profiling to further translational research, focusing on the formidable issues of patient genetic background heterogeneity, matching drugs to tumor genomic profiles in real-time clinical trial settings and the utility of personalized therapeutic interventions.
Genome Sequencing: Discovery and Clinical ApplicationsGail Jarvik, MD, PhD - June 4, 2013
Gail Jarvik, MD, PhD, is head of the Division of Medical Genetics, the Arno G. Motulsky Endowed Chair in Medicine and professor of Genome Sciences at the University of Washington Medical Center. Jarvik discussed emerging issues in clinical genomics, including the return of incidental genomic findings. She also gave an example of the use of genomics to solve the genetic basis of a clinic patient with a novel presentation.
Globally Monitoring Translation One Codon at a Time with Ribosome ProfilingJonathan Weissman, PhD - May 29, 2012
Jonathan S. Weissman, PhD, professor of Cellular & Molecular Pharmacology and Biochemistry & Biophysics, University of California, San Francisco, and investigator at Howard Hughes Medical Institute, discussed the suite of ribosome profiling techniques developed by his laboratory that dramatically expand the ability to follow translation in vivo.
Telomeres, Telomerase and Association with Human DiseaseThomas Cech, PhD - April 5, 2011
Thomas R. Cech, PhD, is distinguished professor, University of Colorado-Boulder; director of Colorado Initiative in Molecular Biotechnology and investigator at Howard Hughes Medical Institute. Cech discussed his laboratory’s research on large noncoding RNAs, where catalysis is carried out by ribonucleoproteins. He described recent research on telomerase and its interaction with chromosome ends.
Resetting Metabolism: Nuclear Receptors and AMPKRonald Evans, PhD - June 1, 2010
Ronald M. Evans, PhD, is professor & March of Dimes chair, Molecular and Developmental Biology, Salk Institute for Biological Studies, and investigator at Howard Hughes Medical Institute. Evans shared his current research on the genetic basis of obesity-related diseases, including diabetes, high blood pressure, heart disease and insulin resistance.
Communicating with Hedgehogs: Signaling in Development and DiseaseMatthew Scott, PhD - May 5, 2009
Matthew Scott, PhD, is professor of Developmental Biology, Genetics and Bioengineering, Stanford University School of Medicine, and investigator at Howard Hughes Medical Institute.
Return to RNAi World: Rethinking Gene Expression, Evolution and MedicineCraig Mello, PhD - May 13, 2008
Craig C. Mello, PhD, is the Blais University Chair in Molecular Medicine, University of Massachusetts Medical School, and investigator at Howard Hughes Medical Institute.
Using Simple Cells to Unlock Complex Secrets of BiologySusan Lindquist, PhD - March 27, 2007
Susan Lindquist, PhD is a member of the Whitehead Institute for Biomedical Research and professor in the Department of Biology at MIT. Lindquist is a pioneer in the study of protein folding. She has shown that changes in protein folding can have profound and unexpected influences in fields as wide-ranging as human disease, evolution and nanotechnology.QuickTime format, high resolution
Human Genome Sequence Variation and the Inherited Basis of Common DiseaseDavid Altshuler, MD, PhD - May 30, 2006
Genes for Heart, Kidney and Bone Disease: New Insights from Human Genetic StudiesRichard P. Lifton, MD, PhD - April 19, 2005
Richard P. Lifton, MD, Ph,D is chair of Genetics and Professor of Internal Medicine, Genetics, Molecular Biophysics and Biochemistry at Yale University School of Medicine and investigator at Howard Hughes Medical Institute.
Of Genes and GenomesDavid Botstein, PhD - April 20, 2004
David Botstein, PhD, is Anthony B. Evnin Professor of Genomics and director of Lewis-Sigler Institute for Integrative Genomics at Princeton University.
Human Genomic Variation in Complex DiseaseAravinda Chakravarti, PhD - April 29, 2003
Aravinda Chakravarti, PhD, is a professor and the director of the McKusick-Nathans Institute of Genetic Medicine at The Johns Hopkins University School of Medicine. Chakravarti’s research is aimed at genomic-scale analysis of the human genome and understanding the molecular genetic basis of common genetic disorders using contemporary genomic tools.