Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Scott Lecture Archive

The Center for Genetic Medicine hosts the annual Richard A. Scott, MD Lecture Series, featuring a renowned speaker in the field of genetic medicine.

Ulrike Heberlein, PhD

October 11, 2016

Flies and Alcohol: Interplay of Nature and Nurture

Ulrike Heberlein, PhD is a Senior Fellow and Laboratory Head at the Janelia Research Campus of HHMI. Dr. Heberlein uses the fruit fly Drosophila as a model organism to study the neural and molecular mechanisms underlying drug abuse and addiction. She discussed the mechanisms by which social experiences and stress affect alcohol behaviors.

Sarah C. R. Elgin, PhD
October 14, 2014

Epigenetic Defense Mechanisms: Coping with Transposable Elements in the Drosophila Genome

Sarah C. R. Elgin, PhD is Victor Hamburger Professor of Arts & Sciences, Professor of Biology, and Professor of Genetics, Washington University in St. Louis; and Investigator, Howard Hughes Medical Institute. Dr. Elgin discussed eukaryotic genomes, which contain high levels of transposable elements (TEs) and their remnants, DNA that is commonly packaged for silencing in heterochromatin. Dr. Elgin models how such silencing occurs at the nucleosome level with the fruit fly Drosophila melanogaster, utilizing an alternative pattern of histone modification with association of heterochromatin-specific proteins, notably HP1.

Nicholas Schork, PhD
March 4, 2014

Genomic Profiling and Translational Research: Study Designs, Analyses and Applications

Nicholas J. Schork, PhD is Director of Biostatistics and Bioinformatics, Scripps Translational Science Institute; Director of Research, Scripps Genomic Medicine; Professor, Department of Molecular and Experimental Medicine, The Scripps Research Institute; and Professor of Psychiatry and Biostatistics (adjunct), University of California San Diego. Dr. Schork described studies that use genomic profiling to further translational research, focusing on the formidable issues of patient genetic background heterogeneity, matching drugs to tumor genomic profiles in real-time clinical trial settings, and the utility of ‘personalized’ therapeutic interventions.

Gail Jarvik, MD, PhD
June 4, 2013

Genome Sequencing: Discovery and Clinical Applications

Gail Jarvik, MD, PhD, is Head, Division of Medical Genetics, the Arno G. Motulsky Endowed Chair in Medicine, and Professor of Genome Sciences at the University of Washington Medical Center. Dr. Jarvik discussed emerging issues in clinical genomics, including the return of incidental genomic findings. She also gave an example of the use of genomics to solve the genetic basis of a clinic patient with a novel presentation.

Dr. Weissman

Jonathan Weissman, PhD
May 29, 2012

Globally Monitoring Translation One Codon at a Time with Ribosome Profiling

Jonathan S. Weissman, PhD, Professor of Cellular & Molecular Pharmacology and Biochemistry & Biophysics, University of California, San Francisco; and Investigator, Howard Hughes Medical Institute, discussed the suite of ribosome profiling techniques developed by his laboratory that dramatically expand the ability to follow translation in vivo.

Thomas Cech, PhD
April 5, 2011

Telomeres, Telomerase and Association with Human Disease

Thomas R. Cech, PhD is Distinguished Professor, University of Colorado-Boulder; Director, Colorado Initiative in Molecular Biotechnology; and Investigator, Howard Hughes Medical Institute. Dr. Cech discussed his laboratory’s research on large noncoding RNAs, where catalysis is carried out by ribonucleoproteins (RNP). He described recent research on telomerase and its interaction with chromosome ends.

Ronald Evans, PhD
June 1, 2010

Resetting Metabolism: Nuclear Receptors and AMPK

Ronald M. Evans, PhD is Professor & March of Dimes Chair, Molecular and Developmental Biology, Salk Institute for Biological Studies; and Investigator, Howard Hughes Medical Institute.Dr. Evans shared his current research on the genetic basis of obesity-related diseases, including diabetes, high blood pressure, heart disease and insulin resistance.

Matthew Scott, PhD
May 5, 2009

Communicating with Hedgehogs: Signaling in Development and Disease

Matthew Scott, PhD, is Professor of Developmental Biology, Genetics, and Bioengineering, Stanford University School of Medicine; and Investigator, Howard Hughes Medical Institute.

Craig Mello, PhD
May 13, 2008

Return to RNAi World: Rethinking Gene Expression, Evolution and Medicine

Craig C. Mello, PhD, is the Blais University Chair in Molecular Medicine, University of Massachusetts Medical School; and Investigator, Howard Hughes Medical Institute.

Susan Lindquist, PhD
March 27, 2007

Using Simple Cells to Unlock Complex Secrets of Biology

Susan Lindquist, PhD is a Member of the Whitehead Institute for Biomedical Research and Professor, Department of Biology, MIT. Dr. Lindquist is a pioneer in the study of protein folding. She has shown that changes in protein folding can have profound and unexpected influences in fields as wide-ranging as human disease, evolution, and nanotechnology.

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David Altshuler, MD, PhD
May 30, 2006

Human Genome Sequence Variation and the Inherited Basis of Common Disease

David Altshuler, MD, PhD is the Associate Professor of Genetics and Medicine, Harvard Medical School and Director, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT.

Richard P. Lifton, MD, PhD
April 19, 2005

Genes for Heart, Kidney, and Bone Disease: New Insights from Human Genetic Studies

Richard P. Lifton, MD, PhD is Chair of Genetics and Professor of Internal Medicine, Genetics, Molecular Biophysics, and Biochemistry, Yale University School of Medicine; and Investigator, Howard Hughes Medical Institute

David Botstein, PhD
April 20, 2004

Of Genes and Genomes

David Botstein, PhD is Anthony B. Evnin Professor of Genomics and Director, Lewis-Sigler Institute for Integrative Genomics, Princeton University.

Aravinda Chakravarti, PhD
April 29, 2003

Human Genomic Variation in Complex Disease

Aravinda Chakravarti, Ph.D. is Professor and Director of the McKusick-Nathans Institute of Genetic Medicine at The Johns Hopkins University School of Medicine. Dr. Chakravarti’s research is aimed at genomic-scale analysis of the human genome and understanding the molecular genetic basis of common genetic disorders using contemporary genomic tools.

Patrick Brown, MD, PhD
December 4, 2001

The Genome’s Language

Patrick O. Brown, MD, PhD is Professor, Department of Biochemistry, Stanford University School of Medicine; and Investigator, Howard Hughes Medical Institute. Dr. Brown led the development of DNA microarrays, or “gene chip” technology.