News and Announcements
Read the latest news from Northwestern University Feinberg School of Medicine’s Center for Genetic Medicine. The links below take you to articles where you can learn more about our members' latest achievements, awards and honors.
A new immunotherapy treatment for recurrent B-cell lymphoma was found to be safe in a trial of nearly 350 patients, according to a study published in The Lancet.
Inhibiting an epigenetic regulator called DOT1L could be a key to slowing treatment-resistant prostate cancer, according to a recent Northwestern Medicine study.
Biological sex has a small but ubiquitous influence on gene expression in almost every type of human tissue, according to a new study.
Targeting oxidative stress with a genetic therapy reduced atrial fibrillation in animal models of disease, making this a promising future treatment, according to a study published in Circulation.
Genomic alterations in prostate cancer therapeutic targets were found to be similar between African American and European American men, suggesting that existing precision medicine approaches could equally benefit both groups if applied equitably, according to a recent study.
A machine-learning program called Peakachu can reveal previously unknown chromatin loops, according to a Northwestern Medicine study published in Nature Communications.
A Northwestern Medicine scientist and collaborators have used an AI-enhanced precision medicine approach to combine multiple views of human brain development as they seek to provide a roadmap for what causes subtypes of autism spectrum disorder.
Measuring epigenetic signatures in blood plasma could help classify brain tumors, according to a study published in Nature Medicine.
A specific cell signaling protein may be used to enhance the sensitivity of medulloblastoma tumors to immunotherapy, potentially improving quality of life for patients with the malignant pediatric brain cancer.
A protein gives motile cilia part of their structure, according to a recent Northwestern Medicine study.
A novel compound using diphtheria toxin to attack a signaling pathway implicated in as many as 50 percent of cancers slowed tumor growth, according to a recent study.
The gene transcription machinery that controls circadian rhythms also regulates insulin release in the pancreas, according to a Northwestern Medicine study.
A genetic screen has revealed previously unknown regulators of Foxp3, a transcription factor that, when deactivated, may improve patient response to aggressive cancers.
Genetic mutations in desmoplakin cause left ventricular cardiomyopathy, rather than right ventricular cardiomyopathy as previously believed, according to a recent study.
A novel method to map protein-protein interactions between viruses and their hosts more precisely than current methodologies may help improve the design of antiviral drugs and therapeutic strategies.
Northwestern Medicine scientists have discovered an alternate mechanism for aberrant gene splicing that contributes to T-cell lymphoblastic leukemia, according to a recent study.
A Northwestern Medicine study has uncovered the molecular mechanisms behind the development of autosomal dominant polycystic kidney disease (ADPKD) and a potential drug target.
A new $15 million gift from University trustees and supporters Louis A. Simpson and Kimberly K. Querrey will establish the Simpson Querrey Institute for Epigenetics at Northwestern University Feinberg School of Medicine, boosting the school’s current efforts to study the effects of environment on the regulation of gene expression.
Mutations in the genes RAS and RAF allow cancer cells to create their own nucleotides, fueling cancer growth, according to a recent study published in Molecular Cell.
Supplementing lab animal diets with a chemical precursor of the molecule NAD+ countered certain age-related declines in circadian rhythm function, according to a recent study.
A new Northwestern Medicine study found important differences in rare skin lymphomas stemming from their specific cell of origin and clinical presentations, according to findings published in Nature Communications.
A new Northwestern Medicine study discovered a new and unexpected function for the transcriptional regulator MLL2/COMPASS.
For the first time, advanced prostate cancer has been treated based on the genomic makeup of the cancer, delaying disease progression for patients with a treatment-resistant form of prostate cancer.
A new study has found that genetic alterations in a rare form of leukemia physically change the architecture of DNA, fueling the replication and spread of cancer cells.
A new Northwestern Medicine study has shed light on the complex phenomenon of liver zonation, showing that a protein known as Wnt is required for correct placement of tight junction and cell adhesion proteins within the liver.
Northwestern Medicine investigators have uncovered a novel pathogenic mechanism used by the bacterium Pseudomonas aeruginosa to promote more severe infections.
A new study has found cells with high numbers of centrioles more quickly migrated through layers of tissue, a process known as radial intercalation, which may provide new insights into the development of many cancers.
A new study has helped solve the mystery of how dysfunctional chromosome folding leads to cancer.
The elevated expression of a gene called LY6K was correlated with increased cancer cell growth and resistance to radiation therapy in glioblastoma, according to a recent Northwestern Medicine study.
A DNA transcription mechanism does not work as previously thought, according to a new Northwestern Medicine study.