News and Announcements
Read the latest news from Northwestern University Feinberg School of Medicine’s Center for Genetic Medicine. The links below take you to articles where you can learn more about our members' latest achievements, awards and honors.
Two Northwestern Medicine studies are improving the understanding of epigenetic mechanisms in cancer development and progression, and identifying novel cancer driver genes that may help identify patients who will benefit from immunotherapy.
Mitochondria play a key role in forming the lymphatic vasculature by acting as a metabolic sensor during the migration of lymphatic progenitor cells from the veins.
Northwestern Medicine scientists have discovered a mechanism that makes a prostate cancer-causing protein called FOXA1 more resilient, according to a recent study.
Northwestern Medicine investigators are advancing the understanding of two groups of transcription factors and their role in many neurodevelopmental diseases and cancers, which is essential for developing novel therapeutic approaches.
A massive trove of information produced in a Northwestern-led study will lay the groundwork for understanding sex-related differences in health and disease for decades to come.
Northwestern’s investment in next-generation sequencing is leading to unprecedented avenues of discovery.
Northwestern Medicine scientists discovered mutations in a scaffolding protein contributes to dystonia, an incurable movement disorder.
A team of Northwestern Medicine investigators have identified specific genetic regions that regulate the expression of genes associated with inherited cardiomyopathy and disease severity.
Blocking the arginine methylation pathway, which helps brain tumor cells proliferate by promoting cell division, could improve cancer therapies, according to a recent study.
T-cell acute lymphoblastic leukemia hijacks a signaling pathway to produce nucleotides, a basic building block of life that fuels the growth and spread of the cancer, according to a recent study.
Northwestern Medicine scientists have detailed the diverse function of CDK9-containing complexes and their impact on gene expression in a recent study published in the journal Genes and Development.
A new study published in Nature Communications has found evidence deep within the skin about the mechanisms controlling skin repair and renewal.
Calcium channels commonly found in immune cells are also present in the brain and regulate synaptic plasticity, according to a recently published study.
Listen to the year's most popular episodes of the Breakthroughs podcast, featuring Northwestern Medicine experts discussing COVID-19 research.
Northwestern Medicine scientists have developed a new high-throughput sequencing tool to test how drugs interact with genetically modified cells.
A series of recent discoveries by Northwestern Medicine scientists point to a more nuanced understanding of how epigenetic regulators function.
Northwestern Medicine investigators have discovered that oncogenes contain specific epigenetic markers called broad genic repression domains, which could help identify potential therapeutic targets for cancer treatment.
A new Northwestern Medicine study has identified tissue-specific epigenetic regulators in zebrafish, filling in a longtime gap in the understanding of the organism’s genome.
Mutations in PCM1, a gene involved in the formation of cilia, were linked with schizophrenia in a variety of animal models and in human genome analysis, according to a recent study.
Combining the current standard-of-care chemotherapy drug with a genetic inhibitor may improve treatment for pancreatic ductal adenocarcinoma, according to a recent study published in PNAS.
A newly discovered function of an epigenetic regulator could be a key to new cancer treatments, according to a new study published in Genes and Development.
A group of scientists combined medicinal chemistry and human stem cells to improve a medication treating a cardiac rhythm disorder, a strategy that could be applied broadly.
New findings have revealed previously unknown information about the genetic basis for Armfield XLID syndrome, a rare intellectual disability linked to genetic defects in the X chromosome.
The DNA methylation landscape of regulatory T-cells is more complex than previously understood, according to a new Northwestern Medicine study.
A new immunotherapy treatment for recurrent B-cell lymphoma was found to be safe in a trial of nearly 350 patients, according to a study published in The Lancet.
Inhibiting an epigenetic regulator called DOT1L could be a key to slowing treatment-resistant prostate cancer, according to a recent Northwestern Medicine study.
Biological sex has a small but ubiquitous influence on gene expression in almost every type of human tissue, according to a new study.
Targeting oxidative stress with a genetic therapy reduced atrial fibrillation in animal models of disease, making this a promising future treatment, according to a study published in Circulation.
Genomic alterations in prostate cancer therapeutic targets were found to be similar between African American and European American men, suggesting that existing precision medicine approaches could equally benefit both groups if applied equitably, according to a recent study.