Focus of Work
Bio
The scientific objectives of our laboratory include identifying genes that contribute to cancer metastasis. The major goal of this research is to define important structure/function relationships and provide the biological basis for new therapeutic strategies. Recent studies have generated molecular classification(s) of specific tumors, and have provided new prognostic markers and novel targets for therapeutic intervention based on the convergence of embryonic and tumorigenic signaling pathways....[Read full text]The scientific objectives of our laboratory include identifying genes that contribute to cancer metastasis. The major goal of this research is to define important structure/function relationships and provide the biological basis for new therapeutic strategies. Recent studies have generated molecular classification(s) of specific tumors, and have provided new prognostic markers and novel targets for therapeutic intervention based on the convergence of embryonic and tumorigenic signaling pathways. Current research activities focus on elucidating how regulatory molecules and phenotype control genes govern cell-to-cell and cell-to-matrix interactions, epithelial/mesenchymal transitions, and motility. Specific projects include signal transduction events initiated by cell adhesion molecules and growth factors; factors regulating interconversion of the tumor cell phenotype; novel three-dimensional analysis of cellular invasion through extracellular matrices; regulation of matrix metalloproteinases by tumor and stromal cell interactions; tumor angiogenesis and vasculogenesis; and role of the microenvironment in epigenetic reprogramming of cellular phenotypes.[Shorten text]
Keywords
Select a keyword to see all related Feinberg faculty via the main faculty profile site.
Education and Certification
- PhD: George Washington University (1977)
- Fellowship: Harvard Medical School, Cell & Developmental Biology (1980)
Contact
773-755-6528
Children’s Hospital of Chicago Research Center
2430 N Halsted Street
Chicago IL 60614 3394
m-hendrix( at )northwestern.edu
