Lonnie
D. Shea, PhD
Assistant Professor
Department of Chemical and Biological Engineering
To Contact Dr. Shea:
phone: 847-491-7043
e-mail: l-shea@northwestern.edu
Dr. Shea's website
PubMed
Reference Lookup
Research Interests
The genetics aspects of Lonnie Shea’s laboratory centers on
the development of controlled DNA delivery systems, with their applications
to tissue regeneration and cell biology research. These systems are based
on the release or immobilization of DNA from biocompatible materials. In applications
for tissue regeneration, the materials are processed into three-dimensional
polymers which support cell growth and provide spatially and temporally controlled
DNA delivery. Transgene expression is achieved both in vitro and in vivo,
and can be employed in studies of tissue formation. The procedure for DNA
immobilization is also being developed for the creation of transfected cell
arrays, which have numerous applications to studies of cell function. These
arrays provide a system to correlate gene expression with cellular responses,
and can be used to screen for molecular targets that induce a specific response
within a desired cell population.