Amy
S. Paller, MD
Professor of Pediatrics and Dermatology
Feinberg School of Medicine
Head, Division of Dermatology
Children's Memorial Hospital
To Contact Dr. Paller:
phone: 773-327-1968
e-mail: apaller@northwestern.edu
Dr. Paller's website
PubMed
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Research Interests
Dr. Amy Paller’s involvement in genetics is multifold. She has been
a principal investigator or co-investigator in studies that have revealed
the underlying molecular bases of several genetic disorders of skin, particularly
keratin gene disorders (see CV). Perhaps best known is her work with mosaic
disorders of skin, and my investigations that revealed KRT10 gene mutations
as the cause of epidermal nevi of the epidermolytic hyperkeratotic types (NEJM,
1994). She also uses molecular genetics regularly in her laboratory to overexpress
stably or block transcription of several genes that encode enzymes involved
in synthesis and metabolism of gangliosides as well as of signaling molecules
(e.g. FAK and Akt mutants)in her laboratory’s studies of the effect
of gangliosides on signaling. They have established several cell lines with
modified ganglioside content based on gene modulation as well as mouse tumor
models with altered ganglioside expression and have recently started to develop
transgenic mouse models(F0 stage). Dr. Paller has long been recognized internationally
for her clinical expertise in genetic disorders of the skin, having authored
several dozens of manuscripts on this subject and giving several talks on
genodermatoses and recent research internationally each year.