Stephen
Douglas Miller, PhD
Professor of Microbiology-Immunology
Director, Interdepartmental Immunobiology Center
Congressman John E. Porter Professor of Biomedical Sciences
To Contact Dr. Miller:
phone: 312-503-7674
e-mail: s-d-miller@northwestern.edu
Dr. Miller's website
Research Interests
Dr. Miller’s laboratory investigates the cellular and molecular
mechanisms of multiple aspects of the immunopathogenesis and specific immunoregulation
of T cell-mediated autoimmune responses employing two mouse models of multiple
sclerosis (MS) - Theiler's virus-induced demyelinating disease (a virus-induced
model of MS) and Relapsing Experimental Autoimmune Encephalomyelitis (R-EAE)
(an autoimmune model of MS). Their interests include the study of: the influence
of genetics and infections on the induction and chronic progression of CNS
autoimmune disease; the role of innate immune signals mediated by virus infection
and Toll-like receptor stimuli in the pathogenesis of CNS disease; and the
molecular genetic and cellular mechanisms underlying intrinsic and induced
immune regulation of peripheral T cell responses mediated by CD4+CD25+ T regulatory
cells, antagonists of costimulatory interactions, and by antigen-specific
T cell tolerance.