Jon
Lomasney,
MD
Associate Professor
Departments of Pathology and Pharmacology
To Contact Dr. Lomasney:
phone: 312-503-0450
e-mail: j-lomasney@northwestern.edu
Dr. Lomasney's website
PubMed
Reference Lookup
Research Interests
Lipids are important regulators of the activity of many proteins including
those involved in cardiac, vascular, pulmonary, and neural regulation, yet
little is known about the molecular mechanisms mediating these effects.
The laboratory of Jon
Lomasney is engaged in a program of basic research to elucidate the molecular
mechanisms by which lipids act as specific ligands to regulate cellular responses,
and to investigate in select areas of cardiovascular disease now aberrations
of signaling pathways may play a vital role in the pathogenesis of human disease.
Dr. Lomasney’s lab
has used the family of phosphoinositide-specific phospholipase C isoforms
as a model to study protein-lipid interactions. Upon stimulation by various
hormones these membrane associated enzymes hydrolyze polyphosphoinositides
to yield second messengers such diacylglycerol and inositol 1,4,5-trisphosphate.
These enzymes play important roles in regulating cardiac and neural function.
His lab has engineered numerous transgenic and knockout mouse lines for several
of the delta isoforms. Currently, they are characterizing the phenotypes of
these mice.