William
Karpus, PhD
Professor of Pathology and Microbiology-Immunology
To contact Dr. Karpus:
phone: 312-503-1005
e-mail: w-karpus@northwestern.edu
Dr. Karpus' website
PubMed
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Research Interests
The long term goal of William Karpus’ research program is to develop
an understanding of the mechanisms of tissue-specific lymphocyte recruitment
and accumulation in models of autoimmune disease and hematologic malignancies.
To this end, they have studied the role of chemokines and their receptors
and continue to elucidate the roles of these molecules in lymphocyte migration
utilizing genetically mutant mice. These tools include the construction and
use of both transgenic and targeted gene deficient mice. This genetic approach
to the mechanistic study of chemokine and chemokine receptors in a variety
of murine autoimmune models and tumor metastasis models continues to be a
main component of his programs’ efforts.