Robert
Holmgren,
PhD
Professor
Department of Biochemistry, Molecular Biology and Cell Biology
To Contact Dr. Holmgren:
phone: 847-491-5460
e-mail: r-holmgren@northwestern.edu
Dr. Holmgren's website
PubMed
Reference Lookup
Research Interests
Dr. Holmgren’s research
group studies the process of pattern formation. In particular they are focused
on the Hedgehog signal transduction pathway and its regulation of cell fate
specification. His laboratory’s present goals are to understand how
the signal is relayed from the cell surface to the Ci signaling complex, how
the components of this signaling complex regulate various aspects of Ci function,
and how Ci acts in conjunction with other transcription factors to regulate
the expression of target genes.
All of this work makes extensive use of genetic approaches. Dr. Holmgren and
his researchers are using reverse genetics to identify new components of the
pathway, genetic epistasis and mosaic analysis to study the function of the
components, and transgenic approaches to carry out structure/function experiments.