Karla
Fullner Satchell, PhD
Assistant Professor
Department of Microbiology-Immunology
To Contact Dr. Fullner-Satchell:
phone: 312-503-2162
e-mail: k-satchell@northwestern.edu
Dr. Fullner-Satchell's website
PubMed
Reference Lookup
Research Interests
The lab of Dr. Fullner-Satchell primarily studies the VcRtxA toxin of Vibrio
cholerae: its mechanism of action, interaction with target cells, and
its contribution to the stimulation of inflammation during V. cholerae
infection.
Using genetic manipulation
of the toxin on the chromosome of V. cholerae, they analyze the structure
and function of the toxin by characterizing discrete domains essential for
the toxin-dependent covalent crosslinking of cellular actin.
In the future, Dr. Fullner-Satchell’s
group plans to perform genetic screens of mutant cells in vitro to identify
host factors essential for toxinogenesis. Finally, they are planning to utilize
microarray and proteomic technologies to understand the host response to exposure
to either toxin or whole cell V. cholerae, both in tissue culture
cells and infected tissues.