Sui Huang, PhD

Associate Professor of Cell and Molecular Biology
Feinberg School of Medicine

Research Interests:
We are interested in the functional significance of nuclear compartmentalization in gene expression regulations at normal and diseased conditions. Specifically, we focus on two nuclear organelles, the nucleolus where ribosome synthesis takes place, and the PNC, whose formation is associated with malignancy.

Selected Publications:
Norton, J. T., Wang, C., Gjidoda, A., Henry, R. W. and Huang, S. (2008). The perinucleolar compartment is directly associated with DNA. J Biol Chem.

Kopp, K., Gasiorowski, J. Z., Chen, D., Gilmore, R., Norton, J. T., Wang, C., Leary, D. J., Chan, E. K., Dean, D. A. and Huang, S. (2007). Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells. Mol Biol Cell 18, 394-403.

Chen, D., Dundr, M., Wang, C., Leung, A., Lamond, A., Misteli, T. and Huang, S. (2005). Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins. J Cell Biol 168, 41-54.

Kamath, R. V., Thor, A. D., Wang, C., Edgerton, S. M., Slusarczyk, A., Leary, D. J., Wang, J., Wiley, E. L., Jovanovic, B., Wu, Q. et al. (2005). Perinucleolar compartment prevalence has an independent prognostic value for breast cancer. Cancer Res 65, 246-53.

Chen, D., Belmont, A. S. and Huang, S. (2004). Upstream binding factor association induces large-scale chromatin decondensation. Proc Natl Acad Sci U S A 101, 15106-11.