Sanjiv Shah, MD
Assistant Professor of Medicine
Feinberg School of Medicine
Research Interests
Dr. Shah's research interests involve the genetics of cardiac structure and function. He has conducted genetic studies in the Hutterites, a founder population with reduced genetic and environmental heterogeneity. These studies have focused on heritability and genome-wide association studies (GWAS) of cardiovascular traits such as blood pressure, left ventricular hypertrophy, and cardiac contractility. He is also currently studying genetics of cardiac structure using GWAS of cardiac MRI traits in the Multi-Ethnic Study of Atherosclerosis (MESA), and the genetics of cardiac mechanics using speckle tracking echocardiography in the Hypertension Genetic Epidemiology Network (HyperGEN). Lastly, Dr. Shah is studying the genetic risk factors for connective tissue disease-associated pulmonary arterial hypertension as part of the Northwestern Scleroderma Program.
Select Publication
Shah SJ. Genetics of systemic sclerosis-associated pulmonary arterial hypertension: Recent progress and current concepts. Curr Rheumatol Rep. 2009;11:89-96
Wang Y, O'Connell JR, McArdle PF, Wade JB, Dorff SE, Shah SJ, Shi X, Pan L, Rampersaud E, Shen H, et al. From the cover: Whole-genome association study identifies stk39 as a hypertension susceptibility gene. Proc Natl Acad Sci U S A. 2009;106:226-231
Shah SJ, DeCara JM, Kurina LM, Pollard H, Collins KA, Lammertin G, Shroff SG, Pan L, Sun Y, Thury MJ, et al. Genetic determinants of cardiac contractility: A genome-wide association study [abstract]. J Am Coll Cardiol 2008.
Shah SJ, Ober C, Lang RM. Two-Dimensional Echocardiography Is Superior to M-mode for the Determination of Left Ventricular Mass: Evidence from a Heritability Study [abstract]. J Card Fail 2007. 5. Shah SJ, Ciullo M, Sun Y, Pan L, Nicolae R, Sorice R, Nutile T, R.M. L, Nicolae DL, Ober C. Identification of RGS7 as a novel gene for systolic blood pressure in a genome-wide association study. 2010 [submitted]
