Richard Wunderink, MD

Professor of Medicine, Pulmonary and Critical Care
Feinberg School of Medicine

Research Interest:
De. Wunderink's research interest is the genetics of critical illness. The primary focus has been on community-acquired pneumonia, but also includes nosocomial pneumonia, septic shock, and the acute respiratory distress syndrome (ARDS). We are particularly interested in the pharmacogenomics of immunomodulatory agents for these disorders.

Selected Publications:
Yende, S., Angus, D. C., Ding, J., Newman, A. B., Kellum, J. A., Li, R., Ferrell, R. E., Zmuda, J., Kritchevsky, S. B., Harris, T. B. et al. (2007). 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia. Am J Respir Crit Care Med 176, 1129-37.

Quasney, M. W., Waterer, G. W., Dahmer, M. K., Kron, G. K., Zhang, Q., Kessler, L. A. and Wunderink, R. G. (2004). Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia. Crit Care Med 32, 1115-9.

Waterer, G. W., ElBahlawan, L., Quasney, M. W., Zhang, Q., Kessler, L. A. and Wunderink, R. G. (2003). Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia. Crit Care Med 31, 1367-72.

Yende, S., Quasney, M. W., Tolley, E., Zhang, Q. and Wunderink, R. G. (2003). Association of tumor necrosis factor gene polymorphisms and prolonged mechanical ventilation after coronary artery bypass surgery. Crit Care Med 31, 133-40.

Waterer, G. W., Quasney, M. W., Cantor, R. M. and Wunderink, R. G. (2001). Septic shock and respiratory failure in community-acquired pneumonia have different TNF polymorphism associations. Am J Respir Crit Care Med 163, 1599-604.