Jonathan Jones, PhD

Professor of Cell and Molecular Biology
Feinberg School of Medicine

Research Interests:
The interaction of cells with elements in the extracellular matrix has a profound influence on cellular behavior. The molecular bases of such interactions are the focus of the research that is carried out in the Jones laboratory. It is our long-term goal to define the mechanisms underlying the way matrix elements, via their cell surface receptors, affect development and remodeling of normal and diseased tissue.

Selected Publications:
Budinger, G. R., Urich, D., DeBiase, P. J., Chiarella, S. E., Burgess, Z. O., Baker, C. M., Soberanes, S., Mutlu, G. M. and Jones, J. C. (2008). Stretch-induced activation of AMP kinase in the lung requires dystroglycan. Am J Respir Cell Mol Biol 39, 666-72.

Gonzalez, A., Clairborne, J.N. and Jones, J.C.R. (2008). Integrin crosstalk in endothelial cells is regulated by protein kinase A and protein phosphatase 1. J Biol Chem 283, 31849-60.

Hopkinson, S. B., DeBiase, P. J., Kligys, K., Hamill, K. and Jones, J. C. (2008). Fluorescently tagged laminin subunits facilitate analyses of the properties, assembly and processing of laminins in live and fixed lung epithelial cells and keratinocytes. Matrix Biol 27, 640-7.

Kligys, K., Claiborne, J. N., DeBiase, P. J., Hopkinson, S. B., Wu, Y., Mizuno, K. and Jones, J. C. (2007). The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. J Biol Chem 282, 32520-8.

Bhattacharya, R., Gonzalez, A., Goldman, R.D., Flitney, F.W. and Jones, J.C.R. Beta 3 integrin and kinesin regulate vimentin cytoskeleton interaction with focal contacts. In press, J. Cell Sci.