John A Kessler, MD
Ken and Ruth Davee Professor of Stem Cell Biology
Professor in Departments of Neurology and Molecular Pharmacology and Biological Chemistry
Feinberg School of Medicine
The laboratory of Dr. John Kessler focuses on two general areas, neural stem cells and neurotrophic growth factors. They are interested in defining mechanisms regulating neuronal and glial differentiation of neural progenitor cells, and on understanding how growth factors promote neuronal survival and phenotypic expression. These studies seek to identify the cytokines that regulate stem cell proliferation and differentiation, to define the intracellular signals that transduce their effects, and to understand how the effects of different growth factors are integrated by the progenitor cell. Although the principal focus of these studies is on definition of mechanisms underlying stem cell differentiation, a significant effort is also devoted to applying molecular neurobiology to clinical problems.