Erik Sontheimer, PhD

Associate Professor of Biochemistry, Molecular Biology & Cell Biology
Weinberg College of Arts and Sciences

Research Interests:
The Sontheimer Lab studies the roles of small RNA molecules in the regulation of gene expression, with an emphasis on sequence-directed genetic interference pathways.

Seleceted Publications:
Bellare, P., Small, E. C., Huang, X., Wohlschlegel, J. A., Staley, J. P. and Sontheimer, E. J. (2008). A role for ubiquitin in the spliceosome assembly pathway. Nat Struct Mol Biol 15, 444-51.

Marraffini, L. A. and Sontheimer, E. J. (2008). CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA. Science 322, 1843-5.

Preall, J. B., He, Z., Gorra, J. M. and Sontheimer, E. J. (2006). Short interfering RNA strand selection is independent of dsRNA processing polarity during RNAi in Drosophila. Curr Biol 16, 530-5.

Pellino, J. L., Jaskiewicz, L., Filipowicz, W. and Sontheimer, E. J. (2005). ATP modulates siRNA interactions with an endogenous human Dicer complex. RNA 11, 1719-24.

Pham, J. W., Pellino, J. L., Lee, Y. S., Carthew, R. W. and Sontheimer, E. J. (2004). A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell 117, 83-94.