Transgenic and Targeted Mutagenesis Core
The Northwestern University Transgenic and Targeted Mutagenesis Laboratory (TTML) is a shared resource designed to produce genetically engineered mice for research projects of investigators on the Evanston campus, in the Feinberg School of Medicine, the Robert H. Lurie Comprehensive Cancer Center, and Children’s Memorial Research Center (CMRC).
The transgenic laboratory was first organized at Northwestern University in 1989 as part of the Markey Program in Developmental Biology to provide a resource for generating transgenic mice by pronuclear microinjection. Relocated to the Chicago campus in 2004, the laboratory now provides a broader, more comprehensive range of services to NU investigators, including generation of transgenic mice, gene targeting of embryonic stem (ES) cells, ES cell microinjection into blastocysts, cryopreservation and recovery of mouse embryos, and rederivation of pathogen free mouse strains.
The Transgenic and Targeted Mutagenesis Laboratory is sponsored by:
The Center for Genetic Medicine
The Robert H. Lurie Comprehensive Cancer Center
Center for Comparative Medicine
