Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Events

Feb

26

Understanding Actionable and Uncertain Findings from Clinical Genome, Exome, or Panel Sequencing in Population-Scale Patient Cohorts

Chicago - 1:30 PM - 2:30 PM

Adam S. Gordon, PhD
Senior Fellow, University of Washington Medical Genetics

As genome sequencing based testing continues to expand into regular clinical practice and massive research efforts such as the All of Us Program, we are certain to uncover not only pathogenic variation that requires clinical action, but also a significant amount of variation in these same genes with uncertain consequences to protein function, and, in turn, disease risk. This talk will provide an overview of the rates and types of these actionable and uncertain findings likely to be uncovered in patient sequencing and introduce new approaches that combine patient data, massively parallel functional assays, and bioinformatic analysis to better classify variants of uncertain significance.

Adam graduated in 2009 with a bachelor's degree in biology from the University of Chicago, where he worked on detecting signatures of local and recent human adaptation in diverse global populations under the supervision of Dr. Anna Di Rienzo. After starting graduate work in 2009 at University of Washington Genome Sciences, he joined the lab of Dr. Deborah Nickerson in 2010 to work on the production and analysis of data for the NHLBI Exome Sequencing Project. He completed his Ph.D. in 2015, with a thesis describing patterns of rare and common pharmacogenetic variation within this dataset, the development of a sequencing panel specifically for pharmacogenetic targets, and its deployment across eMERGE, the NHGRI's Electronic Medical Records & Genomics (eMERGE) Network. He then joined the lab of Dr. Gail Jarvik at UW Medical Genetics as a postdoctoral fellow to continue his work with the eMERGE network and gain an understanding of how genomic testing impacts patient care. His current work includes analyzing incidental findings data across the eMERGE network, characterizing actionable and uncertain findings among Colorectal Cancer/Polyps patients, and developing new methods to improve variant classification. A longtime advocate for science education and inclusion, Adam co-founded UW's first organization for LGBTQ graduate students and is a Science Communication Fellow at the Pacific Science Center where he volunteers regularly.

 

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May

02

Can Genetic Technologies Advance Sustainable Agriculture? Perspectives from Research and the Farm (Chicago)

Chicago - 6:00 PM - 7:00 PM

The Center for Genetic Medicine of Northwestern University Feinberg School of Medicine welcomes you to attend the Silverstein Lecture Series on May 2 (Chicago) and May 3 (Evanston), featuring Pamela Ronald, PhD and Jennie Schmidt, MS, RD, in a discussion titled: "Can genetic technologies advance sustainable agriculture? Perspectives from research and the farm." Dr. Ronald is Distinguished Professor, Department of Plant Pathology and the Genome Center and Faculty Director, Institute for Food and Agricultural Literacy, University of California, Davis; and Director of Grass Genetics, Joint Bioenergy Institute. Ms. Schmidt is a farmer at Schmidt Farms Inc. and a Registered Dietician.

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May

03

Can Genetic Technologies Advance Sustainable Agriculture? Perspectives from Research and the Farm (Evanston)

Evanston - 6:00 PM - 7:00 PM

The Center for Genetic Medicine of Northwestern University Feinberg School of Medicine welcomes you to attend the Silverstein Lecture Series on May 2 (Chicago) and May 3 (Evanston), featuring Pamela Ronald, PhD and Jennie Schmidt, MS, RD, in a discussion titled: "Can genetic technologies advance sustainable agriculture? Perspectives from research and the farm." Dr. Ronald is Distinguished Professor, Department of Plant Pathology and the Genome Center and Faculty Director, Institute for Food and Agricultural Literacy, University of California, Davis; and Director of Grass Genetics, Joint Bioenergy Institute. Ms. Schmidt is a farmer at Schmidt Farms Inc. and a Registered Dietician.

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